Electrophysiology CINRE, hospital BORY
Atrial Fibrillation: Guidelines (2026) Compendium / 6.1 Comorbidities and Risk Factors of Atrial Fibrillation

Comorbidities and Risk Factors of Atrial Fibrillation


Comorbidity (associated diagnosis) refers to the presence of one or more additional diagnoses alongside the primary diagnosis. In our case, the primary diagnosis is atrial fibrillation (AF). Patients with AF frequently have other coexisting diseases (diagnoses), collectively referred to as comorbidities.

  • The most common comorbidities in AF: arterial hypertension, diabetes mellitus, heart failure.

Risk factors for AF include habits and unhealthy lifestyle patterns that increase the incidence of AF and worsen its clinical course, as well as other cardiovascular diseases.

  • The most common risk factors for AF: lack of physical activity, alcohol consumption, smoking.

Comorbidities and risk factors increase the incidence of AF and worsen its course (aggravate symptoms and promote AF progression). Adequate treatment of comorbidities and modification of risk factors reduce AF incidence and improve its clinical course.

Infographic illustrating risk factors and comorbidities of atrial fibrillation, including hypertension, obesity, diabetes, heart failure, smoking, and excessive alcohol consumption.
Comorbidities and Risk Factors of Atrial Fibrillation Class
Diagnosis and treatment of comorbidities (associated diseases) and elimination of risk factors are fundamental components of the prevention and management of atrial fibrillation. Comorbidities and risk factors of atrial fibrillation:
  • Arterial hypertension
  • Heart failure
  • Diabetes mellitus
  • Overweight and obesity
  • Lack of physical activity
  • Alcohol
  • Smoking
  • Sleep apnoea syndrome
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Based on data from clinical studies, several comorbidities and risk factors are known to increase the incidence of AF and worsen its clinical course. These include:

  • Arterial hypertension
  • Heart failure
  • Diabetes mellitus
  • Overweight and obesity
  • Lack of physical activity
  • Alcohol
  • Smoking
  • Sleep apnoea syndrome

These guidelines are unofficial and do not represent formal guidelines issued by any professional cardiology society. They are intended for educational and informational purposes only.

Peter Blahut, MD

Peter Blahut, MD (Twitter(X), LinkedIn, PubMed)